What is CBDA
What is CBDA
What is CBDA – Cannabidiol (CBD), a main component in the fibre-type cannabis plant, display a large veriaty of biological activities such as inhibition of cancer cell proliferation, brain damage and enzymes that can cause damage to the body. In fresh plant samples, most of the CBD exist in its acidic form, cannabidiolic acid (CBDA). Over time, the substance goes through a process of carboxylation (the removal of a carboxyl group – oxygen coupled with hydrogen) and transforms into CBD. This process can be accelerated with heating or burning of the cannabis as happens with smoking. The use of this acidic cannabinoid as an active pharmacological component has not yet achieved, that is because prior studies showed that CBDA is the inactive pharmacological form. Spite that being the matter, recent studies show that other than CBD, CBDA itself reveals biological activities that is being antibacterial, anti-tumor, anti temic and is non-psychoactive.
What is CBDA – CBDA decrease nausea and vomiting
What is CBDA – In an experiment conducted on rats, subjects were administered solutions containing CBDA with different concentrations. Some time after, the subjects were administered with emesis inducing solutions, containing lithium chloride (LiCl) or cisplatin. An observer who is not aware to the conditions of the experiment counted the amount of vomiting and nausea, each was counted separately. The same solutions containing CBDA were used in the same experiment to evaluate their effect on rat brain cells tissues and results were measured.
What is CBDA – The result that was observed in the rat experiment showed that CBDA decreased the amount of vomiting and also nausea, that was measured by watching the gaping in each subject, that was caused by the LiCl and cisplatin injections. The brain tissue experiment results showed that CBDA can block the cannabinoid receptor type 1. These results strengthen the claim that this substance contains important therapeutic qualities, treating nausea and vomiting in animal models and supports the hypothesis that CBDA inhibits it, regardless to CB1 receptor, therefore won’t cause an increasing of tolerance to the substance that is dependent on the receptor itself.
What is CBDA – CBDA against breast cancer
What is CBDA – Death that is caused from breast cancer occurs nearly 90% because of metastasis (migration of cancer cells through the blood cells) to the bones and lungs. COX-2 is the name of an enzyme (a protein that changes the structure of molecules) expressed in 40% of the breast cancer cases where metastasis to the bones or lungs is occurring, and it might be an actively involved factor in this process. In an experiment done on breast cancer cell culture, solutions containing CBDA and other material in various concentrations, were incubated along the cultures and samples were taken at different times. An additional analysing method that was used in this experiment, measured the presence of COX-2 in each of the cultures.
What is CBDA – The visible results for the cultures viable count (the amount of subjects in the culture) was not altered, therefore it is safe to say that CBDA is involved in inhibition of breast cancer cell proliferation. The analyzation of enzyme in the cultures reveals that the course of action exhibited by CBDA is occurring in a similar mechanism to its daughter molecule, CBD. It was then concluded that CBDA might target certain genes that their expression could be influenced by by cancer cell density. A profound analysis of COX-2 expression, alongside with CBDA showed that inhibition of COX-2 occurred, therefore CBDA is an inhibitor of COX-2 which is suspected to be involved in breast cancer metastasis.
What is CBDA – CBDA and the difference from CBD
When looking at the results of these studies, one can see some resemblance between CBDA and CBD, knowing that the CBD originated in CBDA. In the experiments presented in this article, CBD was also used as a control group to be compared with, that is because CBD is well studied. Regarding nausea and vomiting treatment, CBDA differs from CBD by showing that its marking CB1 receptor. Likewise in relation to decreasing breast cell proliferation, CBDA showed far less effectiveness other than CBD and is considered a less effective therapeutic agent for this matter, though it inhibits COX-2 in a more effective manner, therefore a combination of them could be effective to prevent cancer of the kind.
What is CBDA – Because of the fact that very few studies were made under the question what is CBDA, it is difficult to foresee its effects on the human body. Personal experiences of cancer patients and other cannabis consumers allows to get a clue about the positive effects of this substance. Many researchers agree that there is a need for further researches in-vivo (in live subjects) conditions.
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