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Relationship between THC and Alzheimer’s Prevention


Relationship between THC and Alzheimer’s Prevention


Relationship between THC and Alzheimer’s Prevention

Relationship between THC and Alzheimer's Prevention

Relationship between THC and Alzheimer’s Prevention

Relationship between THC and Alzheimer’s Prevention – Alzheimer’s disease is the main cause of dementia (dementia – a mental illness which is reflected in a significant drop in cognitive function of the patient. Also known under its new name, numbness) in the adult population. While this population has grown, the number of Alzheimer’s cases occurring as they are expected to triple over the next fifty years. These data are a source of serious concern and this is because modern medications and suffer only a partial success, either to prevent the development of the disease, improve the patient’s quality of life and reduce treatment costs. And pharmaceutical industry invests heavily in research to understand the mechanisms operating in the complex brain and the development of new drugs to improve and stop the progression of the disease while minimizing possible severe side effects that accompany these treatments.
Relationship between THC and Alzheimer’s Prevention – understanding of the mechanisms used by the illness helps researchers understand which direction to attack not only the symptoms but also the source. The effect physiological (physical) of Alzheimer’s disease is manifested in the destruction of brain cells by making deposits Amiloaidiim (a plaque being maintained tangles of fibers), and damages of the central nervous system by breaking down of acetylcholine. The molecule named it, is Niorotrnzmitor (a substance released at the end of sites meeting between nerve cells, also called a synapse, and is used to transfer information between them) located at the intersections neuro-vascular (sites of nerve cells that transmit signals to muscles), on clusters of nerve cells (ganglion) of The internal motor system and many sites in the CNS. While understanding that there is a multi-function of oxyacetylene junior-vascular junctions and synapses ganglion, the actions of acetylcholine in the CNS are not understood until the end. This material speech synthesis at the end of the nerve cells in response involves the enzyme oxyacetylene transferal (CAT). The very presence of nerve cell CAT clearly indicates that acetylcholine (AC) is a compound of his message. After crossing a message delivered through synaptic vesicles that contain any of the many ten thousand molecules AC. [1]
Relationship between THC and Alzheimer’s Prevention – compared to other small molecules Dispatch (especially at intersections junior-vascular), AC is not reabsorbed, but broken down by an enzyme Hidroliti (which requires water to perform actions) strongly called oxyacetylene-est erase (AChE). This enzyme is concentrated in the synapse, ensures a very rapid reduction of concentrations of AC after the release of the pre-synaptic end. The behavior of the enzyme is very fast, and by hydrolysis (using water to dissolve molecules), is a joint five thousand units per second AC unit AChE. Breakdown products are acetate and choline. The activity of AChE inhibitors materials, clinging to the enzyme’s active site forming a covalent bond (a strong bond of sharing electrons). By this action, the site is able to get the molecules are designed to work together with him and so the enzyme becomes seat. AChE introduced in recent years as a booster formation of precipitation Amiloaidim brain by the action of a molecule follows (Peron – Chaperone, associated molecule and leads her through a program under which it is communicated to this site or another molecule). Many drugs based AChE inhibitors are the spearhead in the war against Alzheimer’s disease. [2]
Relationship between THC and Alzheimer’s Prevention – molecule Hfitoknbinoaid Ttrhidroknabinol (THC) was identified and characterized the sixties and since then it has been studied in many field as a natural product analyst nausea, vomiting, infections and I continued to paint. Within these research areas, most dealing effectively becomes the active molecule of attachment to the cannabinoid receptors which are found mainly on the central and peripheral neurons (CB1) or immune cells (CB2). However, recently found a link between Alzheimer’s endocannabinoid system. This relationship has provided a new therapeutic target for patients struggling with the disease. The three experiments which are described here and discussion of their results indicate that THC have the ability to provide preservative properties of neurons from excess precipitation Amiloaidim.
Relationship between THC and Alzheimer’s Prevention – the first test is done using a software called AutoDock that this program helps researchers to speculate how small molecules such as drug candidates Sbostratim or bind to receptors and interact with them. Researchers bound to AChE originating THC mouse. Twenty runs were made of software and Boyle in such areas should include active and inactive regions. The second experiment tested the inhibition of AChE. THC and AChE were mixed with DTNB (reagent widower thiol groups is used for counting fish) solution and incubated at a temperature of 37 degrees. Units of measurement made by absorption spectrophotometer device then calculates the equation is the enzyme AChE activity was delayed as a result of the presence of THC. The third experiment was conducted by measuring the fluorescence intensity of the reaction (generated from a particular material under UV light) of accumulation of sediments Amiloaidim following the activity of AChE under the presence of AChE ligand (substances that bind to it).
Relationship between THC and Alzheimer’s Prevention – the investigators’ conclusion, three trials showed complete inhibition of AChE, and more importantly, THC binds to not only detect but also active Hfrfirali site of the enzyme and thus prevent the accumulation of sediments Hamiloaidim. In contrast to previous studies which directed the use of cannabinoids for the treatment of Alzheimer’s disease, this study provides a mechanism by which the THC molecule capable of directly affect the causes of the disease.
Relationship between THC and Alzheimer’s Prevention


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