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CBD treatment of Alzheimer’s disease

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CBD treatment of Alzheimer’s disease

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CBD treatment of Alzheimer’s disease

CBD treatment of Alzheimer's disease

CBD treatment of Alzheimer’s disease

CBD treatment of Alzheimer’s disease – in 1906, Dr. Eloise Alzheimer studied brain tissue of a woman who died off a mysterious mental illness. Among the symptoms of memory loss appear, language problems and unexpected behavior. After death, the doctor examined her brain and found dense clumps and clusters of fibers. Today, these clumps called plaques Amiloaidim they constitute the main characteristic of Alzheimer’s disease, which is named after the doctor who discovered the phenomenon.
CBD treatment of Alzheimer’s disease – Alzheimer’s disease is an irreversible brain disorder that slowly destroys memory and thinking abilities, until finally it negates the ability to perform simple tasks. This disease occurs mainly in adults in sixties and the most common cause of dementia in this population is. Dementia is a loss of cognitive actions such as thinking, memory and logic. This loss can lead to a situation where the patient’s daily routine is interrupted and the actions that make up the life of the patient. The range in which it operates dementia is the mild which disturbed the normal functioning until very difficult, it is not possible to carry out simple tasks necessary for daily life. Ldinmtzih factors vary, depending on the types of brain changes that occur. Rabbi Alzheimer’s patients experience a combination of at least two types of disorders, Alzheimer’s disease usually combined with vascular dementia. This type of dementia including disorders of the blood supply to the brain, causing a series of minor strokes. Although the main characteristic is the same disease called plaques Amiloaidim agrees, another feature is the loss of connections between brain neurons (nerve cells).
CBD treatment of Alzheimer’s disease– according to most scholars, it seems that brain damage begins a decade before symptoms such as memory loss known and cognitive activities. The destruction process begins in the hippocampus, a brain region that is part of the limbic system (part of the nervous system responsible for emotion, motivation and memory). As more and more dead neurons in the brain affected other parts and they begin to shrink. In the final stages of Alzheimer’s mass of brain cells to shrink significantly. Scientists do not fully understand the causes of Alzheimer’s disease. People experiencing the disease early age, cause genetic mutation associated with. Patients suffering from late onset of their lives, the disease is associated with a combination of genetics, environmental factors and lifestyle. For now, there is no foreseeable treatment for Alzheimer’s disease. Common approaches today are focused on helping patients maintain cognitive function, to manage behavioral symptoms and delay or slow down the symptoms of the disease. Future researchers hope to develop treatments that will be directed at specific genes or molecular and intracellular mechanisms that causes the disease lurking beneath the surface could be stopped or avoided. [1]
CBD treatment of Alzheimer’s disease– Despite advances in the understanding of the mechanisms of Alzheimer’s, modern treatments provide only a limited number of advantages. Today approved four drugs market. Three of them are based on inhibitors of acetylcholinesterase (an enzyme secreted from muscles for the breakdown of acetylcholine, a neurotransmitter associated with the name of the main systems of neurotransmitters in the brain) such as Riooistagmin, donepezil and Galantamin. Fourth based N-Mtil- receptor Antagonist D Asfrtat (NMDA – receptors play an important role in health and function of neurons). Unfortunately these drugs provoke side effects. Acetylcholinesterase inhibitors cause nausea, vomiting, diarrhea and loss of weight and are known to cause hallucinations, dizziness and fatigue. In addition, these drugs do not become the state of the disease, but only symptom care workers, and this particular efficiently.
CBD treatment of Alzheimer’s disease – because conventional therapies are not a solution for the disease, scientists looked up at Knbidiaol which is, CBD. Many studies have shown that the compound which indoor cannabis in the laboratory as proof of neuro-Frotktibiot features (that keep neurons) which may be used to prevent the deterioration of the situation and Hhifokmfim cortical neurons. In addition, CBD showed strong interactions with the endocannabinoid system in several places including the CB1 cannabinoid receptors and CB2 and compound reacts with a variety of systems Niorotrnsmitr (neuron transmits electrical-chemical signals). Great diversity CBD touches that makes him a leading candidate as a drug-modal (a drug on the number of symptoms) for the treatment of Alzheimer’s disease.
CBD treatment of Alzheimer’s disease – in large-scale trials in the CBD and live models not studied on a large scale, you can look at existing experiments carried out in mice to understand the potential of this material. The effects of CBD in mice that were injected with them Aß or A-beta (short protein is a greater involvement in Alzheimer’s disease and forms the plaques found in the brains of patients), was an encouragement. Study conducted in mice receiving A-beta derived from humans and have been treated for seven days through the CBD. This experimental results showed that the CBD was able to download, depending on the amount, activity and expression levels of GFAP protein, known as a significant Bgliaosh reactive (change in cells Glialim cause damage to the central nervous system). Therefore, the results suggest that the CBD was able to inhibit Gliaosh reactive caused from A-beta.
CBD treatment of Alzheimer’s disease – Other experiments conducted in mouse models have shown promising results for the treatment of Alzheimer’s disease and mirrors “mini proven” benefits of this compound offers. It is possible that treatment combining CBD and THC could be more effective. Although should be understood that many trials are needed to understand the potential of the compound to treat the illness most effectively to not cause many side effects. However, the CBD has been shown as available, with limited side effects and is safe for humans.
Sources
https://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289988/

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