cbd and gastrointestinal
cbd and gastrointestinal
cbd and gastrointestinal – the hemp plant was used as a remedy for a variety of diseases throughout history for thousands of years. From ancient China to its westward expansion, the plant was used to treat a variety of maladies ranging from infections, sores in pain and intestinal diseases. Modern science has managed to distinguish and classify plant close to 100 compounds of 500 compounds classified under 18 different chemical classes that are derived from other compounds.
These compounds are formed naturally in plants and are called cannabinoids or Fitoknbinoaidim. Among the studied compounds and the most important are – Ttrhidroknbinol (THC), and Knbidiaol (CBD). THC is the psychoactive compound (chemical substance which affects the consciousness) CBD is non-psychoactive compound.
Other compounds which are Bioaktibit (substances which are able to act in the body) to note are -ttrhidroknbinol (second derivative of THC), cannabinol (CBN), -ttrhidroknbiooarin (THCV) and Knbidiooarin (CBDV). These psychoactive compounds that have less than THC.
During experiments and models Hiitim many clinical trials, it is customary to give the CBD in various ways such as infusion, injection and oral (by mouth to the gastrointestinal tract). Since CBD is a material that reacts living entities is going to change with the insertion digestion and circulation. This fact is important because patients receive and when a certain compound must remain pure as possible in order to be effective. Also, the researchers experimented with CBD can have difficulty in providing an accurate diagnosis of the impact of the material when mixed derivatives of the original compound, due to the presence of many factors experimenter body come into contact with the material (enzymes and acidic environment variable).
cbd and gastrointestinal – researchers at the University of San Diego, which include John Merrick and Brian Lane looked at data from recent studies of epilepsy and had watched a high of AE (Adverse Event – defined as an event in which a patient receives the drug in experiencing undesirable effects and these are not necessarily related to treatment himself).
They witness saw 44% of such events which include sleepiness (witness 21%) and fatigue (witness 17%). If the CBD is not psychoactive, researchers wondered if these symptoms may be a result of findings from other studies that argue that the CBD in an acidic environment quickly breaks down THC and cannabinoids to other Fsicoaktibim.
To test the hypothesis that CBD to THC breaks down the acid conditions of the stomach, the researchers set up an experiment in a lab configuration simulated gastric juice (SGF – Simulated Gastric Fluid) and physiological conditions (such as heat and speed the flow of materials). Because solubility (ability of a material to mix other material) limited the CBD decided to use an active material such premises SDS (Sodium Dodecyl Sulfate – a material with many applications in biological laboratories).
The experiment was carried out using three materials, the CBD, -THC and THC. The materials tested under conditions simulating a chemical bath the acidic environment of the stomach and an additional bath containing physiological solution (HEPES) non-acidic conditions like stomach.
In addition, another solution containing the CBD HEPES solution was tested on an advanced type of HPLC analyzes (High Pressure Liquid Chromatography). The results found were inconclusive, as time passed the more molecules of the CBD have become molecules of THC Delta 8 and 9 of the SGF solution without changing the HEPES solution.
The researchers also were able to find the formula which infer the rate of transformation of this process and the expected output.
Mmsknotihn gastric environment was recorded that other factors will naturally come to mind such as Anzmtit activity, the formation of fat and the amount of food the stomach. According to them, given 700 milligrams of CBD patient, after half an hour will be created 6.5 milligrams of THC Delta 8 and 9, and after an hour, about 13 milligrams.
This reversal of the CBD molecules Hfsicoaktibim components may cause undesirable effects in patients who are given a formula so the researchers suggest finding other ways for the provision of the CBD in order to prevent the formation of psychoactive compounds that appear as a result of the use of oral. 
cbd and gastrointestinal – against this article were two comments criticizing the experiment and suggest that the findings do not endanger the patients participating in the trial. The first reaction came from three researchers from universities in Sao Paulo and-Grotnghrmn Germany in cooperation with Medical Editor cannabinoid research organizations. Their argument is that oral administration of CBD, even in large amounts, causes no figures THC effects in humans.
Critics say that even if the hypothesized has a medicinal value, it can be proved only in clinical practice.
The biological conversion of CBD to THC can be easily recorded through an increase in serum (a clear fluid in blood) of THC or of 11-OH-THC and it has not been demonstrated. According to this, the researchers have raised is whether the conversion occurs at all. 
cbd and gastrointestinal – the second comment relates to the original article and the response of visitors. Addressing the issue of conversion, the second group showed visitors through the presentation of previous articles that the coup also has evidence of CBD to THC indicating the Mtbolotim (breakdown products of the molecule is) of THC. The appearance of characters
THC effects probably associated with these metabolites. It relies on studies and reviews current research show that there is a conversion, although many other factors are expressed at the same time. In addition, studies designated CBD-related tests did not examine in depth the issue of conversion and therefore not documented them in specific symptoms.